When pets can't adapt to stress it can lead to nervousness, hyperactivity, excess barking, abnormal urine marking, excessive scratching, and destructive or aggressive behavior. Calming bite-sized chews for medium & large dogs are designed to support a calm demeanor in your pet during times that they may feel overstimulated or fearful. Calming supports a quiet state and provides a natural way to address stressful situations without a sedative like effect. Recommended for travel, boarding, trips to the veterinarian, fireworks, thunderstorms or any other situations that may cause your pet stress or anxiousness. Calming is not a drug or sedative. It will not cause fatigue or a change in personality, and it may help your pet to be calm in situations where there is a lot of activity going on around them. You can safely administer day to day basis or only in times of high stress for your pet. In times of extreme anxiousness, you can safely double or triple the dose. Calming begins to take effect in as little as 30 minutes and has been clinically shown to work for up to 4 hours.